April 27, 2005
Los Angeles,
CA-
Heart failure associated with pregnancy has been described as a
distinctive form of cardiomyopathy for many years.
Pregnancy-associated cardiomyopathy (PACM) presented in the
peripartum period was later defined as peripartum
cardiomyopathy (PPCM). Classical criteria for diagnosis of PPCM
limited the diagnosis to the last gestational month and first 5
months after delivery. A study published in the
April 26,
2005 issue of Circulation by Uri Elkayam, MD et al from
the University of Southern California Keck School of Medicine
further defined the clinical profile of PPCM. They also compared
the clinical characteristics of patients who meet traditional
criteria of PPCM with those diagnosed with cardiomyopathy
earlier during pregnancy.
Data was
obtained from 123 women with a history of cardiomyopathy during
pregnancy or postpartum period. One hundred women met
traditional criteria for peripartum cardiomyopathy, while 23
were diagnosed with pregnancy-associated cardiomyopathy earlier
than the last gestational month.
Peripartum
cardiomyopathy patients had a mean age of 31 +/- 6 years and
were mostly white (67%). These patients were also found to have
associated conditions such as gestational hypertension (43%),
tocolytic therapy (19%) and twin pregnancy (13%). Left
ventricular ejection fraction at the time of diagnosis was
29+/-11% and improved to 46+/- 14% (P<0.0001) at follow-up.
Maternal Mortality was 9%.
The study
made a comparison between PPCM and early PACM groups, showing no
statistically significant difference in age, race, associated
conditions, left ventricular ejection fraction at diagnosis, its
rate and time of recovery and maternal outcome between the two
groups.
Overall, the
study demonstrated a higher incidence of PPCM in women greater
than 30 years of age. They showed that PPCM was not limited to
black women, which was proposed in previous studies. Multiparity
did not seem to be a risk factor for PPCM, as 40% of the cases
were during the patient’s first pregnancy. The study also showed
a strong association between PPCM and gestational hypertension
and twin pregnancies. This association between hypertension and
PPCM, may indicate that increased blood pressure may be a cause
of heart failure in these patients. The association between twin
pregnancies and PPCM may support an autoimmune mechanism for
PPCM due to increased amount of cell trafficking during
gestation. The high incidence of PPCM in tocolytic therapy may
suggest long-term use of terbutaline tocolysis as a cause of the
cardiomyopathy.
The study
also showed that almost 20% of the patients developed symptoms
and diagnosis of heart failure earlier than the last gestational
month. Thus, clinicians should be aware of the possibility of
early presentation of PACM such that a timely course of
treatment and management can follow diagnosis.
Co-Authors:
Mohammed W. Akhter, MD; Harpreet Singh, MD; Salman Khan, MD;
Fahed Bitar, MD; Afshan Hameed, MD; Avraham Shotan, MD |