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CARDIOLOGY ONLINE NEWS |
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| 23rd WORLD CONGRESS ON HEART DISEASE |
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OCT-GUIDED PCI: PRESENT STATUS AND FUTURE PERSPECTIVES
Takashi Akasaka, M.D., Ph.D., Wakayama Medical University, Wakayama, Japan
Optical coherence tomography (OCT) is thought to be an optical analog of intravascular ultrasound (IVUS) with 10 times higher resolution (10-15µm) and rapid pullback (2-3 cm/sec) with greater accuracy in the measurement compared with IVUS and angiography.MORE»
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HIGHLIGHTS FROM THE 2017 ACC/AHA HYPERTENSION GUIDELINES
Wilbert S. Aronow, M.D., Westchester Medical Center/New York Medical College, Valhalla, NY, USA
A normal blood pressure (BP) is < 120/80 mm Hg. A systolic BP between 120-129 mm Hg with a diastolic BP < 80 mm Hg should be treated by lifestyle measures. MORE»
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BEYOND STENOSIS: PLAQUE AND ISCHEMIA ASSESSMENTS BY CORONARY CTA
Daniel S. Berman, M.D., Cedars-Sinai Medical Center, Los Angeles, CA, USA
Coronary CT angiography (CCTA) is revolutionizing the noninvasive assessment of patients with suspected coronary artery disease (CAD). MORE» |
EVOLVING LANDSCAPE OF ANTITHROMBOTIC THERAPY FOR ATHEROSCLEROSIS
Deepak L. Bhatt MD, MPH, Brigham and Women's Hospital, Boston, MA, USA
Today, MRI is rarely performed in pts with conventional PM/lCDs. While recent studies such as MagnaSafe published in NEJM have unequivocally documented MRI safety in pts with implanted devices, the clinical value has not been considered. MORE»
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PACEMAKER/ICD IN THE MRI ENVIRONMENT; BEYOND THE MAGNASAFE TRIAL
Robert W. Biederman, M.D., Director, Cardiac MRI, Allegheny General Hospital, Pittsburgh, PA, USA
Nonsteroidal anti-inflammatory drugs (NSAIDs) are prescribed frequently. By 2005 observational studies and small randomized trials suggested excess cardiovascular (CV) adversity with some NSAIDs. MORE»
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FILTERING THE EVIDENCE: UPDATES ON IVC FILTERS
Benhood Bikdeli, M.D., Columbia University Medical Center, New York, NY, USA
Pulmonary embolism (PE) is a serious form of venous thromboembolism (VTE), associated with significant risk of mortality, as well as short-term and long-term non-fatal sequelae. MORE»
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NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS): CARDIOVASCULAR EVENTS ARE RELATED PRIMARILY TO IMPACT OF NSAIDS ON BLOOD PRESSURE RATHER THAN TO COX SELECTIVITY
Jeffrey S. Borer, M.D. , Cell Biology, Radiology, Public Health and Surgery, SUNY Downstate, New York, NY, USA
Nonsteroidal anti-inflammatory drugs (NSAIDs), both non-selective and selective cyclooxygenase-2 (COX-2) inhibitors, are very widely prescribed, but they may cause increased blood pressure (BP) and adverse cardiovascular (CV) events. MORE» |
PULMONARY HYPERTENSION - HAVE WE GONE FROM A DEATH SENTENCE TO A "FORGETTABLE DISEASE" FOR MANY IN 30 YEARS?
Robert C. Bourge, M.D., The University of Alabama at Birmingham, Birmingham, AL, USA
Pulmonary arterial hypertension is a group of diseases, probably with a genetic predisposition and possibly an environmental trigger, leading to elevated pulmonary arterial tree resistance, right heart failure, and a generally poor prognosis. MORE»
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ELEVATED SERA SST2 PREDICTS HEART FAILURE IN MEN UNDER THE AGE OF 50 WITH CLINICAL SUSPECTED MYOCARDITIS
Katelyn A. Bruno, Ph.D., Cardiovascular Diseases, Mayo Clinic, Jacksonville, FL, USA
Objective: Myocarditis is an important cause of heart failure. Men with myocarditis have worse recovery and an increased need for transplantation compared to women, but the reason for the sex difference remains unclear. MORE» |
SEX DIFFERENCES IN EXERCISE DURATION TIME AND RISK OF CARDIOVASCULAR DISEASE EVENTS IN HEALTHY ADULTS
Yzhar Charuzi, M.D., Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA
We aimed to evaluate sex differences in cardiorespiratory fitness in a relatively healthy population and its association with cardiovascular disease (CVD) events. MORE» |
MANAGEMENT OF METABOLIC SYNDROME AND ATHEROSCLEROSIS IN MULTIPLE MOUSE MODELS OF HUMAN TYPE II DIABETES AND HEART DISEASE
Subroto B. Chatterjee, Ph.D., Johns Hopkins University, Baltimore, MD, USA
Background- Metabolic syndrome is defined by increased levels of LDL cholesterol and triglycerides and decreased levels of HDL cholesterol. MORE» |
FRAILTY AND CLINICAL OUTCOMES OF TRANSCATHETER AORTIC VALVE REPLACEMENT
Asim N. Cheema, M.D., St. Michael's Hospital, Toronto, ON, Canada
Aortic stenosis (AS) is the most common valvular heart disease among Western populations and severe AS has an estimated prevalence of 3-4% among people older than 75 years of age. MORE»
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HEARTFUL LIVING: PROGRAM FOR IMPROVING HEALTH & LIFESTYLE THROUGH SELF-AWARENESS
Anand Chockalingam, M.D., University of Missouri, Columbia, MO, USA
Heartful living is a cardiac wellness program that simplifies yoga principles to expand its applicability to all ages and abilities. MORE»
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RAPAMYCIN PROTECTS DIABETIC RABBIT HEARTS AGAINST ISCHEMIA/REPERFUSION INJURY BY REGULATING PTEN-AKT SIGNALING
Anindita Das, Ph.D., Virginia Commonwealth University, Pauley Heart Center, Richmond, VA, USA
Background: Diabetes is a major risk factor for myocardial infarction (MI). Persistent activation of the mammalian target of rapamycin (mTOR) leads to diabetic complications and plays a critical role in myocardial reperfusion injury... MORE»
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PEDIATRIC AND ADULT CONGENITAL ARRHYTHMIAS MANAGEMENT: TECHNIQUES AND CHALLENGES
Srikant Das, M.D.,
University of Arkansas for Medical Sciences, Little Rock, AR, USA
1. Unusual accessory pathways: pathways with Mahaim characteristics can be atriofascicular, atrioventricular, nodofascicular and nodoventricular, depending on their variable proximal and distal insertions. MORE» |
HIS BUNDLE PACING
Abhishek J. Deshmukh, M.D., Mayo Clinic, Rochester, MN, USA
Right ventricular apical pacing is associated with an increased incidence of heart failure, atrial fibrillation, and overall mortality. MORE»
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STORE OPERATED Ca2+-CHANNEL BLOCKERS AS A POTENTIAL THERAPY FOR HYPERTENSION
Naranjan S. Dhalla, Ph.D., M.D., St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada
Background and Objectives: Hypertension is invariably associated with elevated levels of intracellular Ca2+, which is determined by the functional status of both L-type Ca2+-channels and store-operated Ca2+channels as well as Na+-Ca2+ exchange system in the vascular smooth muscle. MORE»
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LIFE SIMPLE SEVEN AND INCIDENCE OF CORONARY ARTERY DISEASE: THE MILLION VETERAN PROGRAM
Luc Djousse, M.D.,
Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
Background: The Association of Life’s Simple 7 (LSS) with incidence of coronary artery disease (CAD) among US veterans has not been evaluated. MORE»
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GENETICS OF VALVE DISEASES
Ronen Durst, M.D., Cardiology Department, Hadassah Hebrew University Medical Center. Jerusalem, Israel
Valve diseases are very common and are the cause of considerable morbidity and mortality. Some of these diseases were shown to have a strong heritability index. MORE»
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GENETICS OF THORACIC AORTIC ANEURYSM 2018
John A. Elefteriades, M.D., Yale University School of Medicine, Aortic Institute at Yale-New Haven, New Haven, CT, USA
Background: Hereditary factors play an important etiologic role in thoracic aortic aneurysm and dissection (TAAD), with a number of genes proven to predispose to this condition. MORE»
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CARDIOVASCULAR DISEASE RISK AND MENOPAUSE: WHAT HAVE WE LEARNED FROM SWAN?
Samar R. El Khoudary, Ph.D., Graduate School of Public Health University of Pittsburgh, Pittsburgh, PA, USA
Despite the recent declines in cardiovascular disease (CVD) burden, CVD remains the leading cause of death in women. MORE»
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PREVENTION OF MYOCARDITIS/DCM USING REGENERATIVE MEDICINE THERAPY
DeLisa Fairweather, Ph.D.,
Mayo Clinic, Jacksonville, FL, USA
Objective: Myocarditis is an important cause of acute and chronic heart failure with no good therapy to reduce/prevent disease. MORE»
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ADIPOSE TISSUE SURFACE-EXPRESSION OF LDLR AND CD36; LINK TO RISK FACTORS FOR TYPE 2 DIABETES IN NORMOCHOLESTEROLEMIC SUBJECTS
May Faraj, Ph.D., University of Montréal/ Clinical Research Institute of Montréal (IRCM), Montréal, QC, Canada
Background/Hypothesis: LDLC-lowering variants are linked to higher diabetes risk. Underlying mechanisms are unknown; however, a role for LDL receptor (LDLR) pathway was proposed. MORE»
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ENHANCING INFLAMMATION RESOLUTION IN ACUTE CORONARY ARTERY DISEASE: THE NEXT FRONTIERS FOR THERAPY?
Janos G. Filep, M.D., University of Montreal, Montreal, QC, Canada
Inflammation underlies development and progression of atherosclerotic plaques from nascent lesions to rupture of fibrous cap that precipitate acute coronary syndromes (ACS). MORE»
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WHAT IF WE HAD A GOOGLE MAP OF THE HUMAN VASCULATURE
Zorina S. Galis, Ph.D., National Institutes of Health, Bethesda, MD, USA
Advances in biomedical knowledge and technologies, including genetics, imaging, and big data analysis and computational tools are increasing our ability to aim for precision medicine. MORE»
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NOVEL ULTRASOUND IMAGING STRATEGIES FOR ISCHEMIC HEART DISEASE
Julius M. Gardin, M.D., Rutgers New Jersey Medical School, Newark, NJ, USA
Practice guidelines for stable ischemic heart disease have outlined the role of coronary CT angiography (CCTA) and cardiac magnetic resonance (CMR), in addition to stress echocardiography and radionuclide myocardial perfusion imaging (MPI) MORE»
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TOWARDS A COMPLETE TRUE HYBRID TREATMENT OF ATRIAL FIBRILLATION
Sandro Gelsomino, M.D., Ph.D., University of Maastricht, Maastricht, Netherlands
Background: Ultrasound technology is Background: There is general agreement amongst experts that there is a pressing need for new tools and techniques to improve the outcome of AF treatment. MORE» |
T3 VERSUS METOPROLOL TREATMENT OF RATS WITH MYOCARDIAL INFARCTION - AND THE WINNER IS?
A. Martin Gerdes, Ph.D., New York Institute of Technology, Old Westbury, NY, USA
Background: Beta blockers are standard therapy for myocardial infarction (MI). MORE» |
MYOCARDIAL BRIDGES DIAGNOSTICS
Olena Gogayeva, Ph.D., National Amosov Institute of Cardiovascular Surgery NAMS of Ukraine, Kiev, Ukraine
Objective: To improve myocardial bridges (MB) diagnostics.
Method: For all patients (pts) we performed ECG, ECHO & coronary angiography. MORE»
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ASPIRIN IN THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE: NEED FOR INDIVIDUAL CLINICAL JUDGMENTS
Charles H. Hennekens, M.D., Dr.P.H., Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Ratan, FL, USA
Background: In secondary prevention, among patients who have survived a wide range of prior occlusive vascular events, as well as during acute myocardial infarction and occlusive stroke, aspirin produces absolute reductions on clinical cardiovascular events that far exceed any absolute risks on major bleeding. MORE»
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SELECTIVE SYSTEMIC AND LOCAL REGULATOR OF SMOOTH MUSCLE CELL FUNCTION VIA THE CANONICAL WNT-PATHWAY: LESSONS LEARNED IN MICE AND MEN
Randolph Hutter, M.D., Bassett Medical Center, Cooperstown, NY, USA
Smooth muscle cell (SMC) function critically influences the clinical course of vascular disease. MORE»
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CARDIOVASCULAR ACTIVATION DURING SOCIALLY EVALUATED COLD-PRESSOR TEST IS ASSOCIATED WITH CHANGES IN IMMUNE FUNCTION BUT NOT WITH ACTIVATION OF STEROID STRESS HORMONES
Daniela Jezova, M.D., Institute of Experimental Endocrinology, BMC, Slovak Academy of Sciences, Bratislava, Slovakia
Cold and other environmental stressors are known to affect blood pressure and heart rate. MORE» |
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CARDIOLOGY ONLINE NEWS |
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| 23rd WORLD CONGRESS ON HEART DISEASE |
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DO NEW STUDIES/DEVICES TIP THE BALANCE TO EARLIER LVAD IMPLANTATION AS DESTINATION THERAPY?
Maryl R. Johnson, M.D., University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
The rapidly advancing field of left ventricular assist device (LVAD) use engenders hope that pts with less advanced heart failure might benefit from LVAD implantation. MORE»
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UP-TO-DATE MANAGEMENT OF ATRIAL TACHYARRHYTHMIAS IN ADULT CONGENITAL HEART DISEASE
Anna N. Kamp, M.D., Pediatric Cardiology, Nationwide Children’s Hospital and The Ohio State University
Columbus, OH, USA
Rhythm disorders are the leading cause of morbidity and mortality in adults with congenital heart disease (ACHD). MORE» |
TRIALS AND TRIBULATIONS OF SLOW CONTINUOUS ULTRAFILTRATION FOR MANAGEMENT OF ACUTE HEART FAILURE - AN UPDATE FOR 2018
Amir Kazory, M.D. , University of Florida, Gainesville, FL, USA
Heart failure remains a major public health concern because of its high prevalence, morbidity, mortality, and financial burden. MORE»
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FRAMEWORK FOR WEARABLE TECHNOLOGIES IN CARDIOLOGY
Ilan Kedan, M.D., Cedars Sinai Smidt Heart Institute, Beverly Hills, CA, USA
Background: The field of cardiology has long used wearable medical devices to monitor heart rate and rhythm. MORE» |
ANTIPLATELET THERAPY FOR PERIPHERAL INTERVENTIONS: AN UPDATE FOR 2018
Rami N. Khouzam, M.D., University of Tennessee Health Science Center, Memphis, TN, USA
Peripheral arterial disease (PAD) is a common disorder associated with a high risk of cardiovascular mortality and continues to be under-recognized. MORE» |
DOES CARDIORESPIRATORY FITNESS MODULATE THE INCIDENCE OF TYPE 2 DIABETES IN PATIENTS ON STATIN THERAPY
Peter Kokkinos, Ph.D., Veterans Affairs Medical Center and Georgetown University School of Medicine, Washington, DC, USA
Objective: Several studies have reported a higher, dose-related risk for developing type 2 diabetes mellitus (T2DM) in those treated with statins compared to placebo or standard care. MORE»
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LYSOSOMAL CYSTEINE PROTEASES AND DISTURBANCES OF THEIR REGULATION IN ATHEROSCLEROSIS
Tatiana A. Korolenko, Ph.D., Institute of Physiology and Basic Medicine, Novosibirsk, Russia
Objectives. Hyperlipidaemia increases the risk of myocardial infarction and stroke. MORE»
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A NEW APPROACH TO HEART VALVE DISEASE: INTERVENTION OR PREVENTION?
Robert A. Levine, M.D., Massachusetts General Hospital, Boston, MA, USA
Heart valve disease creates a major public health burden of heart failure and death, currently met with interventional repair and replacement. MORE» |
DECIPHERING THE ROLE OF MITOPHAGY-LYSOSOME DYSFUNCTION IN THE DIABETIC HEART
Qiangrong Liang, M.D., Ph.D., New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA
Mitochondrial dysfunction plays an important role in diabetic heart damage. MORE»
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MODULATION OF INFLAMMATORY VASCULITIS (IVS) AND ANTI-INFLAMMATORY TREATMENT BY THE GUT MICROBIOTA - A MOUSE HERPESVIRUS IVS MODEL
Alexandra R. Lucas, M.D., Biodesign Institute, Arizona State University, Tempe, AZ, USA
Objective - Inflammatory vascular syndromes (IVS) are rare but devastating arterial disorders. MORE» |
CALCIUM SCORING - WHERE DO WE STAND IN 2018?
John J. Mahmarian, M.D., Weill Cornell Medical College, Houston Methodist Hospital, Houston, TX, USA
Coronary artery calcium score (CACS) testing has been studied for 30+ yrs with extensive evidence supporting it use for identifying coronary atherosclerosis, assessing patient risk and guiding patient management. MORE»
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NANOMEDICAL STUDIES OF ENDOTHELIAL AGING IN THE CARDIOVASCULAR SYSTEM
Tadeusz Malinski, Ph.D., Ohio University, Athens, OH, USA
Background: Dysfunction of endothelium, followed by a decrease in the efficiency of the cardiovascular system, can be directly related to biological aging. MORE» |
DAYLIGHT SAVING TIME AND ACUTE MYOCARDIAL INFARCTION: DOES A GENDER-ORIENTED DIFFERENCE EXIST?
Roberto Manfredini, M.D., Center for Studies on Gender Medicine, University of Ferrara, Ferrara, Italy
Objective: Daylight Saving Time (DST) is applied in many countries to prolong the sunlight proportion of the day. MORE» |
LOW T/HIGH T TESTOSTERONE AND THE HEART
James D. Marsh, M.D., University of Arkansas for Medical Sciences, Little Rock, AR, USA
Assessment of the QT interval is an important marker for drug-induced cardiac toxicity and risk of sudden death. The most frequently used formulae to correct the QT for heart rate (QTc) were developed, almost 100 years ago in 1920 by Bazett (QTcBZT) using the square root of the heart rate... MORE» |
PCSK9 EXPRESSION IN THE ISCHEMIC HEART AND ITS RELATIONSHIP TO INFARCT SIZE AND CARDIAC FUNCTION
Jawahar L. Mehta, M.D., Ph.D., University of Arkansas for Medical Science, Little Rock, AR, USA
Background: Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a novel therapy to treat hypercholesterolemia and related cardiovascular diseases. MORE»
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GENETICS IN THE MANAGEMENT OF DILATED CARDIOMYOPATHY
Luisa Mestroni, M.D., University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Nonischemic dilated cardiomyopathy (DCM) is a common heart disease, associated with high risk of progressive heart failure, arrhythmia and sudden cardiac death. MORE» |
FASTING IS NOT NECESSARY FOR LIPID TESTING: NIHIL PER OS NON IAM
Samia Mora, M.D.,
Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Robust evidence supports the use of non-fasting blood draws for routine clinical practice and widespread adoption would be favorable for both patients and healthcare providers. MORE» |
INITIAL INTRAVASCULAR ULTRASOUND IN THE EVALUATION OF CARDIAC TRANSPLANT VASCULOPATHY WITHOUT A ROUTINE EARLY BASELINE STUDY HAS PROGNOSTIC VALVE
Mohammad-Reza Movahed, M.D., Ph.D., CareMore and University of Arizona, Tucson, AZ, USA
Background: Abnormal minimal intimal thickening (MIT) on Intravascular ultraousnd (IVUS) defined as difference of > 0.5 mm between baseline and one-year post-transplantation has been shown to have prognostic value. MORE»
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THROMBOLYTICS VERSUS PUMP EXCHANGE IN VAD MANAGEMENT: SHOULD WE USE A TAILORED APPROACH?
Nandini Nair, M.D., Ph.D., Texas Tech Health Sciences Center, Lubbock, TX, USA
Objective: To assess current treatment modalities for pump thrombus. MORE»
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UNUSUAL ARRHYTHMIC CAUSES OF SYNCOPE
Hakan Paydak, M.D., University of Arkansas for Medical Sciences, Little Rock, AR, USA
In a pooled data from 5 population-based studies of Syncope, aproximately 20% of the cohort had a cardiac origin. MORE» |
SPONTANEOUS CORONARY ARTERY DISSECTION: FURTHER INSIGHTS UTILISING BIG DATA
Rahul Potluri, M.D., ACALM, Birmingham, UK
Spontaneous coronary artery disease (SCAD) has been increasingly recognized as one of the causes of Acute Coronary Syndrome particularly in younger women. MORE» |
ORIFICE ECCENTRICITY ACCENTUATES FLOW DISTURBANCE DUE TO SEVERE MITRAL ANNULAR CALCIFICATION
Gregg S. Pressman, M.D., Department of Cardiology, Einstein Healthcare Network, Philadelphia, PA, USA
Background: Mitral annular calcification (MAC) deforms the valve reducing its opening. The narrowed orifice may disturb vortex formation in the left ventricle (LV)... MORE» |
NHLBI WORKING GROUP RECOMMENDATIONS ON CALCIFIC AORTIC VALVE DISEASE: THE CHAIRMAN'S PERSPECTIVE
Nalini M. Rajamannan, M.D., Mayo Clinic, Rochester, MN, and Most Sacred Heart of Jesus Cardiology and Valvular Institute,
Sheboygan WI, Corvita, Chicago IL, USA
In 2009, NHLBI coordinated a working group on Calcific aortic valve disease. For decades, the disease was thought to be due to a degenerative process. MORE»
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SEX DIFFERENCES IN PERIPHERAL ARTERIAL DISEASE: DIAGNOSIS, SYMPTOMS AND TREATMENT
Judy Regensteiner, Ph.D., University of Colorado, School of Medicine, Aurora, CO, USA
Approximately 8-12 million people in the US have peripheral artery disease (PAD). Although it used to be thought that women were less likely to be diagnosed with PAD, in fact women now are estimated to comprise about half of this group. MORE» |
OPTIMIZING STATIN UTILIZATION AND TREATMENT ADHERENCE AMONG PATIENTS WHO DISCONTINUE STATINS DUE TO ADVERSE MUSCLE EVENTS - A PERSONALIZED APPROACH
Robert S. Rosenson, Ph.D.,
Icahn School of Medicine at Mount Sinai, New York, NY, USA
Statin therapy has been established as first-line therapy for the prevention of atherosclerotic cardiovascular disease (CVD) events. MORE»
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SILENCING OF THE CARDIAC 18-kDa TRANSLOCATOR PROTEIN PREVENTS HEART FAILURE DUE TO PRESSURE OVERLOAD
Saul Schaefer, M.D., University of California Davis, Davis, CA, USA
Rationale: Heart failure (HF) is characterized by abnormal mitochondrial calcium (Ca2+) handling and energy production which ultimately results in contractile dysfunction and myocyte death. MORE» |
ADIPOCYTES PROMOTE IL18 BINDING TO ITS RECEPTORS DURING ABDOMINAL AORTIC ANEURYSM FORMATION IN MICE
Guo-Ping Shi, SC.D., D.SC., Brigham and Women's Hospital, Boston, MA, USA
IL18 receptor (IL18r) and Na-Cl co-transporter (NCC) both mediate IL18 actions. We reported that IL18 use both IL18r and NCC as its receptors and participate directly in atherogenesis. MORE»
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HOME HOSPITALIZATION FOR ACUTE DECOMPENSATED HEART FAILURE: OPPORTUNITIES AND STRATEGIES FOR IMPROVED HEALTH OUTCOMES
Marc A. Silver, M.D.,
University of Illinois, Chicago, IL, USA
Care of patients with chronic heart failure is a highly integrated process, and requires exquisite attention to detail, clear team communication, adherence to protocols and evidence guided therapies and well-conceived and short, medium and long strategic approaches. MORE» |
TRICUSPID REGURGITATION - CURRENT AND EMERGING THERAPIES
Siddharth Singh, M.D.,
Cedars-Sinai Heart Institute, Los Angeles, CA, USA
Tricuspid Regurgitation(TR) is commonly noted on echocardiograms performed for various reasons. In the last two decades clinical significance of hemodynamically significant TR has increasingly been well recognized. MORE»
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INDIVIDUALIZATION OF OPTIMAL TREATMENT FOR STABLE ANGINA PECTORIS: AN ONGOING CHALLENGE
Udho Thadani, M.D. ,
University of Oklahoma HSC, Oklahoma City, Oklahoma and VA Medical Center, Oklahoma City, OK, USA
Patients with angina pectoris may have underlying obstructive or non- obstructive disease, or even normal coronary arteries, which may account for their symptoms. MORE» |
MECHANISM OF CARDIOVASCULAR REMODELING IN HEART FAILURE
Suresh C. Tyagi, Ph.D.,
University of Louisville School of Medicine, Louisville, KY, USA
Remodeling and myocardial matrix metabolism contributes to cardiac endothelium–myocyte (perivascular fibrosis), myocyte–myocyte (interstitial fibrosis), and mitochondrion–myocyte (fusion and fission) coupling. MORE»
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TARGETING CaMKII IN HEART FAILURE
Yang-Gan Wang, M.D., Ph.D.
Zhongnan Hospital of Wuhan University, Wuhan, China
There is growing body of evidence suggesting that CaMKII is an important sensor for the altered Ca2+ handling in heart failure (HF). MORE» |
CARDIAC TARGETING PEPTIDE; A NOVEL CARDIAC TARGETING PROTEIN TRANSDUCTION DOMAIN
Maliha Zahid, M.D., Ph.D.,
University of Pittsburgh, Pittsburgh, PA, USA
Background: Cardiac diagnostics and therapeutics are limited by lack of cardiac-specific vectors. Cell penetrating peptides are small peptides able to carry intact the cell membrane barrier. MORE»
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