Cardiology Online - International Academy of Cardiology
»search site
The International Academy of Cardiology is dedicated to the advancement of global research in cardiovascular medicine through the support of scientific meetings and publications.
   Home Page
   Discussion Groups
   Job Opportunities
   Contact Us





19th World Congress on Heart Disease



Amir Kazory, M.D., University of Florida, Gainesville, FL, USA


Simultaneous dysfunction of the heart and the kidney represents a distinct spectrum of disease states composed of complex clinical scenarios with potentially adverse outcomes. Worsening renal function (WRF) in the setting of acute decompensated heart failure (ADHF) is one such clinical setup with not yet well-characterized underlying mechanisms. It is of paramount importance to characterize the pathways leading to WRF in ADHF in order to develop a mechanistically-relevant management strategy. There has been a shifting paradigm in our understanding of the cardiorenal interactions in patients with ADHF questioning some contemporary concepts such as the low forward flow theory or high backward pressure hypothesis. Besides, emerging data do not fully support our conventional thinking about other aspects of these interactions such as the independent adverse impact of WRF on the outcomes of patients with ADHF, pointing to congestion as a possibly overlooked factor. The findings of the recent studies also suggest that apparent improvement in renal function might be yet another risk factor for untoward outcomes in this patient population, further challenging our current understanding of the cardiorenal interactions. This talk will provide a brief overview of these emerging controversies in the field of cardiorenal syndrome with the goal of identifying the areas where clinical research can be most helpful to fill the gaps in our understanding.



©1998-2015 Cardiology Online, Inc. All rights reserved.
Cardiology Online is a registered trademark of Cardiology Online, Inc.