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 Editor: Asher Kimchi, MD

Intracoronary Injection of Mononuclear Bone Marrow Cells in Acute Myocardial Infarction Found No Effects on Global Left Ventricular Function
The net loss of cardiomyocytes during myocardial infarction is a key factor in the impairment of cardiac-pump function. The bone marrow contains stem cells that have shown promising results in solid-organ repair and regeneration.  Ketil Lunde M.D. et al from the Rikshospitalet University Hospital in Oslo, Norway designed a randomized, controlled trial to investigate the effects of intracoronary injection of autologous cells from bone marrow (BMC) in the acute phase of myocardial infarction. They investigated whether there was any improvement in left ventricular function after the treatment. The study, published in the September 21, 2006 issue of The New England Journal of Medicine, found no effects of intracoronary injection of autologous mononuclear BMC on global left ventricular function. MOREĽ

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