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 Editor: Asher Kimchi, MD

Decontamination of Nasopharynx and Oropharynx with Chlorhexidine Gluconate Appears to Reduce Nosocomial Infection After Cardiac Surgery
Nosocomial infections after open-heart surgery are recognized as an important cause of complications and mortality. Patrique Segers, MD et al from the University of Amsterdam set out to determine the efficacy of perioperative decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate for reduction of nosocomial infection after cardiac surgery. Their study, published in the November 22/29 issue of the Journal of the American Medical Association found that decontamination with chlorhexidine gluconate appears to be an effective method to reduce nosocomial infection after cardiac surgery. MOREĽ

Propionyl-L-Carnitine Improves Hemodynamics and Metabolic Markers of Cardiac Perfusion during Cardiopulmonary Bypass Coronary Surgery in Diabetic Patients

Unfavorable metabolic changes and impaired endothelial function in diabetic patients make them more susceptible to post-operative complications in cardiopulmonary bypass coronary surgery (CPB). It has been shown that carnitine administration in such patients can improve cardiac metabolism and function in ischemic patients. Suggested mechanisms include an increase in glucose metabolism and reduction of toxic effects of long-chain acyl-Co-A. Romauld Lango et al from the Medical University Gdansk, Poland evaluated hemodynamic changes associated with pre-operative propionyl-L carnitine and L-carnitine administration and its association with biochemical markers of cardiovascular function. Their study, published in the December 2005 issue of Cardiovascular Drugs and Therapy indicates a significant improvement of hemodynamics following propionyl-L carnitine administration in diabetic patients undergoing coronary-artery bypass grafting (CABG). MOREĽ

Coronary-Artery Bypass Grafting is Associated with Higher Rates of Survival than Stenting for Patients with Coronary Artery Disease
Coronary-Artery Bypass Grafting (CABG) and percutaneous coronary intervention (PCI) have been the predominant therapeutic procedures for coronary artery disease. Though stenting procedures have made great advancements over the last few years, there have been no recent studies comparing the outcomes of stenting and CABG. Edward Hannan M.D. et al from the University at Albany, State University of New York used observational data from a large registry to compare short-term and long-term outcomes among patients with multi-vessel disease who underwent CABG or stenting. The study was published in the May 26, 2005 issue of The New England Journal of Medicine and found that for patients with two or more diseased coronary arteries, CABG is associated with higher adjusted rates of long-term survival than stenting. MORE…
Vascular Surgery Patients on Statins Have Fewer Cardiac Complications

Robotic heart surgery: making repairs without lifting the hood

Sirolimus Reduces Acute Rejection and Coronary Artery Disease in De Novo Heart Transplant Patients






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