Folic Acid and B Vitamins Do Not Reduce the Risk
of Major Cardiovascular Events in Patients With
Vascular Disease
Observational studies suggest that mild
to moderate elevations in homocysteine levels
may increase cardiovascular disease. Folic acid,
vitamin B12, and vitamin B6 lower plasma
homocysteine levels. The Heart Outcomes
Prevention Evaluation (HOPE) 2 study in Ontario,
Canada investigated whether supplementation with
folic acid and vitamins B12 and B6 reduce the
risk of major cardiovascular events in high risk
patients. The trial found that daily
administration of folic acid and vitamins B6 and
B12 lowered homocysteine levels but did not
reduce the incidence of major cardiovascular
events. These results were published in the
April 13, 2006 issue of The New England
Journal of Medicine.
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