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20th World Congress on Heart Disease

 

 

 


20th World Congress on Heart Disease


  IAC MEETINGS

  IAC

International Academy of Cardiology
Annual Scientific Sessions 2015
20th World Congress on Heart Disease



vancouverHyatt Regency Vancouver
Vancouver, BC, Canada
July 25-27, 2015

 

Abstract Deadline:
February 10, 2015


CME Meeting

Publication of Abstracts:
Accepted abstracts will be published in a special online only supplement issue of the journal CARDIOLOGY.

Affiliated with:
American College of Cardiology, California Chapter


The American Society for Preventive Cardiology

Endorsed by:
Heart Valve Society of America


   
         
   
Video from the 16th World Congress on Heart Disease      
 

MEETINGS AFFILIATED WITH THE IAC


Controversies and Advances in the Treatment of Cardiovascular Disease: The Fourteenth in the Series
November 20-21, 2014
The Beverly Hills Hotel
Beverly Hills, CA, USA

Tel Aviv 9th International Conference on Acute Cardiac Care
January 18-20, 2015
Tel Aviv, Israel

Advances in Nuclear Cardiology and Cardiac CT: 30th Annual Case Review with the Experts with 101 Evidence-based Cases
January 23-25, 2015
Los Angeles, CA, USA

19th Annual Heart Failure 2015 - Update on Diagnosis and Therapy
April 18, 2015
Los Angeles, CA, USA



To see more information on Meetings Offered in Cooperation with the International Academy of Cardiology, click here.


 
 PREVIOUS MEETINGS OF THE IAC
 


boston International Academy of Cardiology
Annual Scientific Sessions 2014
19th World Congress on Heart Disease


Hyatt Regency, Boston, MA, USA
July 25-28, 2014

CME Meeting
Final Program
Download the final program (pdf)

The scientific program of the 19th World Congress on Heart Disease has been reviewed by the American Medical Association and approved for 23.25 AMA PRA Category 1 Credits™.

Publication of Abstracts:
Accepted abstracts will be published in a special online only supplement issue of the journal CARDIOLOGY.

Affiliated with:
American College of Cardiology, California Chapter

The American Society for Preventive Cardiology

Endorsed by:
Heart Valve Society of America


toronto
International Academy of Cardiology
18th WORLD CONGRESS ON HEART DISEASE
Annual Scientific Sessions 2013

July 26-29, 2013
Hyatt Regency, Vancouver, BC, Canada

CME Meeting
Photo Gallery
Final Program
Download Final Program (pdf)

The scientific program of this Congress has been reviewed by the American Medical Association and approved for a maximum of 25.75 AMA PRA Category 1 Credits™.

Publication of Abstracts:
Accepted abstracts were published in a special online only supplement issue of the journal CARDIOLOGY. Click here to view.


Affiliated with:
American College of Cardiology, California Chapter

The American Society for Preventive Cardiology

Endorsed by:
Heart Valve Society of America


 


Photos from the 18th World Congress on Heart Disease (click here to see more photos)

   toronto 

International Academy of Cardiology
17th WORLD CONGRESS ON HEART DISEASE

Annual Scientific Sessions 2012
July 27-30, 2012
The Fairmont Royal York,
Toronto, ON, Canada

Final Program
Final Program (pdf)

Affiliated with
American College of Cardiology, California Chapter

The American Society for Preventive Cardiology

Endorsed by
Heart Valve Society of America

CME Meeting
*Approved by the American Medical Association for a maximum of 23.75 AMA PRA Category 1 Credits™.

Sending your Article(s) to Monduzzi Editore - Medimond's Proceeding Book

 

Photos from the 17th World Congress on Heart Disease
(Click here to see more photos)

      
International Academy of Cardiology
16th WORLD CONGRESS ON HEART DISEASE

Annual Scientific Sessions 2011
July 23-26, 2011
Hyatt Regency Vancouver, BC, Canada

Final Program
Final Program (pdf)

Program at a Glance (pdf)

Writing Instructions and Sending your Article(s) to Monduzzi Editore - Medimond's Proceeding Book

Affiliated with the American College of Cardiology, California Chapter

CME Meeting

*Approved by the American Medical Association for a maximum of 32.25 AMA PRA Category 1 Credits™.

photos Click here to view photos from the 16th World Congress on Heart Disease


New Horizons in Cardiovascular Disease15th WORLD CONGRESS ON HEART DISEASE
International Academy of Cardiology
Annual Scientific Sessions 2010

July 24-27, 2010
Vancouver, BC, Canada

(click to view index as pdf)

Proceedings Book
ISBN: 978-88-7587-617-3
Available also on CD-ROM


Photos from the 15th World Congress on Heart Disease
(Click here to see more photos)

FINAL PROGRAM
*Approved by the American Medical Association for a maximum of 26.25 AMA PRA Category 1 CME Credits™ 

Endorsed by the American College of Cardiology, California Chapter


Current Advances in Heart Disease14th WORLD CONGRESS ON HEART DISEASE
International Academy of Cardiology
Annual Scientific Sessions 2008

July 26-29, 2008
Toronto, ON, Canada

(click to view index as pdf)

Proceedings Book
ISBN: 978-88-7587-480-3
Available also on CD-ROM

FINAL PROGRAM
*Approved by the American Medical Association for a maximum of 26.25 AMA PRA Category 1 CME Credits™ 

Endorsed by the American College of Cardiology, California Chapter


14th World Congress on Heart Disease

Recent Advances in Cardiovascular Disease 13th WORLD CONGRESS ON
HEART DISEASE

International Academy of Cardiology
Annual Scientific Sessions 2007
July 28 - 31, 2007
Hyatt Regency Vancouver
Vancouver, B.C., Canada

Proceedings Book
ISBN: 978-88-7587-369-1
Available also on CD-ROM


Photos from the 13th World Congress on Heart Disease
(Click here to see more photos)

FINAL PROGRAM & ABSTRACTS
*Approved by the American Medical Association for a maximum of 27 AMA PRA Category 1 CME Credits™  



Advances in Heart Disease INTERNATIONAL ACADEMY OF CARDIOLOGY
12th WORLD CONGRESS ON HEART DISEASE
- NEW TRENDS IN RESEARCH, DIAGNOSIS AND TREATMENT
July 16-19, 2005
Vancouver, BC, Canada


Proceedings Book
ISBN: 88-7587-192-2
Available also on CD-ROM


 Photos from the
12th World Congress on Heart Disease

[Click here to see more photos]

FINAL PROGRAM & ABSTRACTS
* Approved by the American Medical Association for 26.25 AMA PRA Category 1 CME Credits


To see more information on Previous IAC Meetings, click here.

 

PREVIOUS MEETINGS AFFILIATED WITH IAC

18th Annual Heart Failure 2014 - Update on Diagnosis and Therapy
April 5, 2014
Millennium Biltmore Hotel
Los Angeles, CA, USA

New YorkValves in the Heart of the Big Apple VIII: Evaluation & Management of Valvular Heart Disease 2014
May 8-10, 2014
Marriott Marquiz, New York City, NY





cancun
Cardiovascular Disease Prevention 2014: Novel Strategies and Emerging Therapies
February 14-17, 2014
Hilton Molino Stucky
Cancun, Mexico


Venice 3rd International Congress on Cardiac Problems in Pregnancy
February 20-23, 2014
Hilton Molino Stucky
Venice, Italy



Advances in Nuclear Cardiology and Cardiac CT: 29th Annual Case Review with the Experts with 101 Evidence-based Cases
January 24-26, 2014
Cedars-Sinai Medical Center
Los Angeles, CA, USA



Controversies and Advances in the Treatment of Cardiovascular Disease: The Thirteenth in the Series
November 21-22, 2013
The Beverly Hills Hotel
Beverly Hills, CA, USA

 


To see more information on Previous Meetings Under the Auspices of the International Academy of Cardiology, click here.

 

  CARDIOLOGY ONLINE NEWS

Invited Speaker Presentations at the
18th World Congress on Heart Disease (cont'd)

(click on the photo to view the video)

18th WORLD CONGRESS ON HEART DISEASE

PROTEIN TRANSDUCTION DOMAINS; TARGETED VS. NON-TARGETED TISSUE DELIVERY

(click on the photo to view the video)

Zahid
Maliha Zahid, M.D., University of Pittsburgh, Pittsburgh, PA, USA

The ability of certain proteins to cross cell membrane barriers was a chance finding reported over 20 years ago. This ability, also termed protein transduction, is localized to 6-30, basic, cationic peptide motifs, known as protein transduction domains (PTDs). MORE»

OMEGA-3 SUPPLEMENTATION IMPROVES ARTERIAL STIFFNESS AND BIOMARKERS OF CV RISK IN LATINO AND WHITE PATIENTS WITH HYPERTENSION SERVED BY A SAFETY-NET HEALTHCARE SYSTEM
(click on the photo to view the video)

Long
Carlin S. Long, M.D., University of Colorado Health Sciences Center and Denver Health Medical Center, Denver, CO, USA

We previously reported on a cross sectional study of Latino and White hypertension patients in a safety-net healthcare system in which Framingham risk factors, markers of inflammation (hsCRP, LPpLA2), arterial stiffness (Pulse wave velocity, augmentation index, and central aortic pressure), and endothelial function (brachial artery flow-mediated dilatation) were measured. MORE»

THE EVOLUTION OF THE PACING SITE: PAST, PRESENT AND FUTURE
(click on the photo to view the video)

Oginosawa
Yasushi Oginosawa, M.D., University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, Japan

As cardiac pacing system for bradyarrhythmias has been developed in clinical practice over half century, the preferential pacing site has been also evolved.[PAST] In the early stage, the object of the pacing was only maintenance of heart rate and pacing lead has been implanted to right atrial appendage and/or right ventricular apex for easiness in terms of implantation and the stability even using conventional passive fixation lead. MORE»

PROTECTIVE EFFECT OF TELMISARTAN AGAINST ENDOTHELIAL DYSFUNCTION AFTER CORONARY DRUG-ELUTING STENT IMPLANTATION IN HYPERTENSIVE PATIENTS
(click on the photo to view the video)

Terashima
Mitsuyasu Terashima, M.D.,
Toyohashi, Japan

Objectives: The aim of this prospective, randomized study was to evaluate the effects of telmisartan on endothelial function after coronary drug-eluting stent (DES) implantation in hypertensive patients, compared to a calcium channel blocker, amlodipine. MORE»

HUMAN ENTEROVIRUS PERSISTENCE: POTENTIAL FOR EXACERBATION OF MYOCARDITIS
(click on the photo to view the video)

Chapman
Nora M. Chapman, M.D., University of Nebraska Medical Center, Omaha, NE, USA

Human enteroviruses like the group B coxsackieviruses (CVB) are known to cause human inflammatory cardiomyopathies but until recently, the CVB were thought to be acute infections, rapidly cleared by the host's immune system. We discovered that CVB can persist for weeks to months following either experimental inoculation (in cell cultures or mice) or natural infection (humans) through a mechanism that involves the loss of the 5' terminal genomic sequence. MORE»

NEUTROPHILS IN ACUTE CORONARY ARTERY DISEASE
(click on the photo to view the video)

Filep
Janos G. Filep, M.D., Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada

Neutrophil granulocytes are present in atherosclerotic lesions and contribute to inflammatory tissue injury underlying all phases of atherosclerosis from nascent lesions to culmination in acute coronary artery disease (CAD). Acute CAD is characterized by widespread neutrophil accumulation, neutrophil infiltration of culprit lesions and prolonged neutrophil lifespan. MORE»

CRYPTOGENIC STROKE - COULD LONG TERM CARDIAC MONITORING UNCOVER THE CAUSE
(click on the photo to view the video)

Gimbel
J. Rod Gimbel, M.D., Knoxville, TN, USA

"Cryptogenic Stroke" is defined as an ischemic stroke that is not attributable to a cardioembolic source or large or small vessel disease whose cause remains undetermined after an extensive cardiovascular and hematologic search for the cause. Approximately, 20-25 % of ischemic strokes are "cryptogenic" with some due to unrecognized or undetected atrial fibrillation. MORE»

MACROPHAGES TRANSMIT POTENT PROANGIOGENIC EFFECTS OF oxLDL IN VITRO AND IN VIVO INVOLVING HIF-1a ACTIVATION: A NOVEL ASPECT OF ANGIOGENESIS IN ATHEROSCLEROSIS
(click on the photo to view the video)

Hutter
Randolph Hutter, M.D., The Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA

Background: Neovascularization has been linked to the progression and vulnerability of atherosclerotic lesions. Angiogenesis is increased in lipid-rich plaque. Hypoxia-inducible factor alpha (HIF-1a) is a key transcriptional regulator responding to hypoxia and activating genes, which promote angiogenesis, among them vascular endothelial growth factor (VEGF). MORE»

IMPACT OF LIFE STYLE MODIFICATIONS, ANTIANGINALS, ANTIPLATELETS AND LIPID MODIFYING DRUGS AND OF CORONARY ARTERY REVASCULARIZATION ON MORTALITY AND MORBIDITY IN PATIENTS WITH ISCHEMIC HEART DISEASE: TRUTH AND FALSE NOTIONS
(click on the photo to view the video)

Thadani
Udho Thadani, M.D.
, University of Oklahoma HSC and VA Medical Center, Oklahoma City, OK, USA

Stable ischemic heart disease (SIHD) is a new term in vogue; and one must address not only the impact of treatment on symptoms and quality of life but also on mortality and other serious adverse cardiovascular outcomes (SACO) such as myocardial infarction (MI) and stroke. Lifestyle alterations (abstinence of smoking, regular exercise and lipid modifying treatment with statins, reduce the incidence of SACO. MORE»

INTEGRATIVE THERAPY IN CARDIOVASCULAR DISEASE: SAVIOR OR SHAM?
(click on the photo to view the video)

Schaefer
Saul Schaefer, M.D., University of California, Davis, CA, USA

While physicians generally treat cardiovascular disease and risk factors with conventional medications such as statins and beta blockers, patients often use complementary or integrative therapy such as fish oil, vitamins, enzymes, and chelation therapy. This $45 billion industry is based on the belief that non-allopathic therapies can lower cardiovascular risk in addition to, or in lieu of, conventional therapy. The NIH Center for Complementary and Alternative Medicine supports therapy "for which there is some high-quality scientific evidence of safety and effectiveness"; MORE»

MEDICAL RISK FACTOR CONTROL IN LARGE TRIALS OF DIABETIC PATIENTS UNDERGOING CORONARY REVASCULARIZATION
(click on the photo to view the video)

Farkouh
Michael E. Farkouh, M.D., University of Toronto, Toronto, Ontario, Canada

Over the past 2 decades, significant progress has been made in the medical management for patients with coronary artery disease (CAD). Despite guidelines that recommend specific targets for control of risk factors, specifically blood pressure targets in hypertensive patients, low-density lipoprotein (LDL) for those with hyperlipidemia, and glycemic control (HbA1C) in diabetic patients, current large cohort studies demonstrate that a significant proportion of patients do not achieve target risk factor control. MORE»

USE OF AMBULATORY BLOOD PRESSURE MONITOR (ABPM) FOR GUIDING CARDIAC PATIENTS MANAGEMENT
(click on the photo to view the video)

Charuzi
Yzhar Charuzi, M.D.
, UCLA School of Medicine, CA, USA

24-hours ambulatory blood pressure monitoring has been for years a useful tool to assess variability in blood pressure beyond office checks or self-measurement. We decided to investigate the impact of ABPMs on patient management. The common indication for applying the test was uncertainty of BP fluctuations over a course of 24 hours. MORE»

CHANGES IN HEART ALLOCATION FOR TRANSPLANTATION IN THE US AND WORLDWIDE: OPTIONS FOR A BETTER SOLUTION
(click on the photo to view the video)

Meyer
Dan M. Meyer, M.D., University of Texas Southwestern, Med Center at Dallas, Dallas, TX, USA

Objectives: To inform the transplant community of potential modifications in the heart allocation system. Background: Efforts to increase transplantation rates for candidates with highest waiting mortality and offer the greatest survival benefit due to transplantation remains the goal of our current systems. MORE»

SIMULTANEOUS HEART-KIDNEY TRANSPLANTATION
(click on the photo to view the video)

Johnson

Maryl R. Johnson, M.D.
, University of Wisconsin-Madison, Madison, WI, USA

Only around 70 heart-kidney transplants are performed worldwide annually, representing 2-3% of heart transplants and 0.5% of kidney transplants. However, due to the shortage of donor kidneys (in the United States over 95,000 people are waiting for a donor kidney and only 11,000 deceased donor kidney transplants are performed annually), it is important that all candidates receiving a heart-kidney transplant truly need the kidney. MORE»

SCREENING FOR ASYMPTOMATIC CORONARY ARTERY DISEASE: SEEKING VALUE IN A MULTI-MODALITY WORLD
(click on the photo to view the video)

Mahmarian
John J. Mahmarian, M.D., Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, TX, USA

There are multiple potential candidate testing modalities for evaluating patients at risk for coronary artery disease (CAD) which include stress ECG testing; stress echocardiography and myocardial perfusion imaging (MPI); and cardiac computed tomography (CT). Stress echocardiography and MPI are considered inappropriate in low and intermediate risk patients but may have value in patients at high CAD risk. MORE»

ULTRAFILTRATION IN THE TREATMENT OF VOLUME OVERLOAD DUE TO HEART FAILURE
(click on the photo to view the video)

Elkayam
Uri Elkayam, M.D.
, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA

Volume overload leading to both hemodynamic and symptomatic congestion is the cause for hospitalizations in the majority of cases with heart failure (HF). Ultrafiltration (UF) has been traditionally used for removal of volume in patients with diuretics resistance and those who need removal of a large volume. MORE»

USE OF NMR LDL LIPOPROTEIN PARTICLE ANALYSIS IN CARDIOVASCULAR DISEASE PREVENTION
(click on the photo to view the video)

Kopecky
Stephen L. Kopecky, M.D., Mayo Clinic, Rochester, MN, USA

Low density lipoprotein particle counts, assessed by NMR technology, is available and is a valuable adjunct to the standard lipid profile normally used in lipid management. This technology is most useful in the following 3 settings: MORE»

DEVICE CLOSURE OF ASD- LONG-TERM FOLLOW UP WITH SPECIAL REFERENCE TO COMPLICATIONS
(click on the photo to view the video)

Sadiq
Masood Sadiq, M.D.
, The Childrens Hospital, Punjab Institute of Cardiology, Lahore, Pakistan

Device closure of ASD is now standard of treatment for suitable defects. There are however concerns over long-term outcome of device closure with special reference to complications mainly erosions and aortic regurgitation. The long term data is now available. MORE»

CORONARY ARTERY CALCIUM DENSITY AND CARDIOVASCULAR DISEASE EVENTS
(click on the photo to view the video)

Criqui
Michael H. Criqui, M.D., University of California, San Diego, La Jolla, CA, USA

Background: Coronary artery calcium (CAC) measured by computed tomography (CT) has strong predictive value for incident cardiovascular disease (CVD) events. The standard CAC score is the Agatston, which is weighted upward for greater calcium density. MORE»

CVD IN WOMEN: A FRESH PERSPECTIVE
(click on the photo to view the video)

Kazory
Amir Kazory, M.D.
, University of Florida, Gainesville, FL, USA

While peritoneal dialysis is an established therapy for management of patients with end stage renal disease, it has also been proposed as a means of fluid and sodium extraction in patients with heart failure and volume overload. A number of studies have used this therapeutic modality in various settings and have generally reported positive results. MORE»

IS THERE A PERFECT APPROACH FOR ABLATION PERSISTENT ATRIAL FIBRILLATION?
(click on the photo to view the video)

Srivathsan
Komandoor Srivathsan, M.D., Mayo Clinic, AZ, USA

Ablation of paroxysmal atrial fibrillation that remains symptomatic despite tolerated antiarrhythmic medication is widely utilized with reasonable success. However, ablative approach in persistent atrial fibrillation remains unclear. Pulmonary vein isolation remains the cornerstone but what additional procedures need to be done to enhance the poor success rate remains inconclusive. MORE»

THE ROLE OF NITRIC OXIDE/PEROXYNITRITE IMBALANCE IN THE ISCHEMIC HEART
(click on the photo to view the video)

Malinski
Tadeusz Malinski, Ph.D.
, Ohio University, Ohio, USA

Background: The functional endothelial cells are the main source of nitric oxide (NO) in the heart. NO release in the beating heart is stimulated by mechanical forces during systole and diastole. NO release can be also stimulated in the heart by chemical pathways, i.e. epinephrine. MORE»

ANTICOAGULATION AND HEART VALVE DISEASE: IS IT TIME TO RECONSIDER WHO AND HOW?
(click on the photo to view the video)

Borer
Jeffrey S. Borer, M.D., New York, USA

Intra cardiac thrombosis and thromboembolism long have been associated with heart valve diseases (VHD). However, except when atrial fibrillation (AF) coincides with VHD, anticoagulation seldom is considered unless a valve has been replaced, particularly with a mechanical prosthesis. MORE»

ANY DEGREE OF MITRAL REGURGITATION FOUND DURING INVASIVE VENTRICULOGRAPHY IS ASSOCIATED WITH ALL CAUSE MORTALITY
(click on the photo to view the video)

Movahed
Mohammad R. Movahed, M.D.
, PhD., Arizona, USA

Background: Using a large data base of patients who underwent coronary angiography for clinical reason, we evaluated association between reported degree of mitral regurgitation (MR) with all-cause mortality. MORE»

CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA: THE CLINICIAN'S PERSPECTIVE
(click on the photo to view the video)

LaPage
Martin J. LaPage, M.D.
, Michigan, USA

Catecholaminergic polymorphic polymorphic ventricular tachycardia (CPVT) is a potentially lethal, genetic channelopathy syndrome characterized by ventricular arrhythmias occurring primarily during exercise. Patients typically present with syncope or seizures and initial misdiagnosis is common because baseline cardiac testing is normal. MORE»

MICROBIOTA, SYSTEMIC INFLAMMATION AND CARDIOVASCULAR FUNCTION
(click on the photo to view the video)

Navab
Mohamad Navab, Ph.D.
, David Geffen School of Medicine, University of California Los Angeles, CA, USA

Inflammation contributes to different degrees to most if not all pathological conditions. The GI system including small intestine plays a major role in systemic inflammation and thus cardiovascular well being. MORE»

LEFT ATRIAL APPENDAGE CLOSURE
(click on the photo to view the video)

Bertog Stefan C. Bertog, M.D., CardioVascular Center, Frankfurt, Germany

Atrial fibrillation is a frequent cause of stroke. The mechanism in non-valvular atrial fibrillation is thrombus formation in the left atrium. Ninety percent of left atrial thrombi occur in the left atrial appendage. MORE»

BIVENTRICULAR PACING FOR ATRIOVENTRICULAR BLOCK AND SYSTOLIC DYSFUNCTION
(click on the photo to view the video)

Curtis Anne B. Curtis, M.D., Buffalo, New York, USA

Background: Right ventricular pacing restores an adequate heart rate in patients with atrioventricular block, but high percentages of right ventricular apical pacing may promote left ventricular systolic dysfunction. We evaluated whether biventricular pacing might reduce mortality, morbidity, and adverse left ventricular remodeling in such patients. MORE»

REVERSAL OF CARDIAC REMODELING IN HEART FAILURE BY ALPHA-ADRENOCEPTOR BLOCKADE
(click on the photo to view the video)

Dhalla Naranjan S. Dhalla, Ph.D, M.D., MB, University of Manitoba, Winnipeg, Manitoba, Canada

In view of the role of elevated levels of circulating catecholamines, the activation of both alpha-adrenoceptor (AR) and beta-AR is considered to play a critical role in the pathogenesis of heart failure. Previous studies have shown the beneficial effects of beta-AR blockade in the failing heart; however, very little information on the action of alpha-AR blockade is available. MORE»

ALDOSTERONE - A BRIDGE BETWEEN CARDIOVASCULAR AND MOOD DISORDERS?
(click on the photo to view the video)

Jezova Daniela Jezova, M.D., Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic

Aldosterone is the main mineralocorticoid hormone involved in the control of blood volume. Its effects on water-electrolyte homeostasis have impact on the control of blood pressure and cardiovascular functions. It is well known that the comorbidity of cardiovascular and mental disorder is high, however, aldosterone has not been implicated in the psychopathology so far. MORE»

 

 

Invited Speaker Presentations at the
17th World Congress on Heart Disease (cont'd)

(click on the photo to view the video)

AORTIC DISEASE

THERE IS AN EFFECTIVE MEDICAL TREATMENT FOR THORACIC AORTIC ANEURYSM

(click on the photo to view the video)

Elefteriades
John A. Elefteriades, M.D.,
Yale University School of Medicine, New Haven, CT, USA

Objective: The potential of medical therapy to influence the courses and outcomes of patients with thoracic aortic aneurysms is not known. The aim of this study was to determine whetherstatin intake is associated with improved long-term outcomes in these patients. MORE»

 

CARDIOVASCULAR IMAGING

PROGRESS IN ECHOCARDIOGRAPHY
(click on the photo to view the video)

Nanda
Navin C. Nanda, M.D.,
University of Alabama at Birmingham, Birmingham, AL, USA

Echocardiography has today become the most widely used technique in the noninvasive assessment of cardiac disease entities. It began in the fifties and sixties as A-mode and M-mode echocardiography in which a pencil-thin ultrasound beam was sent to the heart by placing a small transducer on the chest wall and images of very small portions of cardiac structures were obtained at any given time. MORE»

 

CARDIOVASCULAR SURGERY

MANAGEMENT OF EARLY POSTOPERATIVE CORONARY ARTERY BYPASS GRAFT FAILURE

(click on the photo to view the video)

Perrault
Louis P. Perrault, M.D., Ph.D.,
Montreal Heart Institute, Montreal, QC, Canada

Objectives: Perioperative graft failure following coronary artery bypass grafting may result in acute myocardial ischemia. Whether acute percutaneous coronary intervention, emergency reoperation, or conservative intensive care treatment should be used is currently unknown. MORE»

DESIGN OF FUTURE REVASCULARIZATION EVALUATION IN PATIENTS WITH DIABETES MELLITUS: OPTIMAL MANAGEMENT OF MULTIVESSEL DISEASE (FREEDOM TRIAL)
(click on the photo to view the video)

Farkouh
Michael E. Farkouh, M.D.,
University of Toronto, ON, Canada

Indication: Treatment of multivessel coronary artery disease (CAD) in patients with diabetes. Objective: To evaluate whether percutaneous coronary intervention (PCI) with drug-eluting stenting (PCI/DES) is more or less effective than the existing standard of care, coronary artery bypass surgery (CABG). MORE»

 

RISK FACTORS AND PREVENTION

STATINS FOR THE PRIMARY PREVENTION OF CVD IN WOMEN
(click on the photo to view the video)

Mora
Samia Mora, M.D.,
Brigham and Women's Hospital, Boston, MA, USA

The use of statins in patients with manifest cardiovascular disease (CVD) is established, with similar benefit in women and men, but statin use for primary prevention of CVD is controversial particularly for women. We analyzed sex-specific outcomes in JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) and conducted an updated meta-analysis of statin use for women in primary prevention (20,147 women, >276 CVD events, mean age 63-69 years). MORE»

 

METABOLIC SYNDROME AND DIABETES



  CARDIOLOGY ONLINE NEWS

The Cardiology Online Journal
 Editor: Asher Kimchi, MD

Distinguished Cardiologists and Scientists Honored with 2014 International Academy of Cardiology Awards at the 19th World Congress on Heart Disease, Boston, MA, USA

2014 AwardsDr. Asher Kimchi, Founder and Chairman of the International Academy of Cardiology (IAC) announced the winning recipients of the 2014 IAC Awards at the 19th World Congress on Heart Disease held in Boston, MA, USA. In addition to the IAC awards, the committee also named four faculty to receive the Distinguished Fellowship Award.

Dr. Asher Kimchi, together with Co-Chairmen Dr. Jeffrey S. Borer and Dr. John A. Elefteriades, headed a committee comprised of 225 of the world's leading cardiologists and scientists that reviewed a prestigious list of nominees and voted for their top choice.

The following awards for 2014 were presented at the Opening Ceremony of the International Academy of Cardiology Annual Scientific Sessions 2014, 19th World Congress on Heart Disease, to honor the memory of distinguished colleagues, all former members of the faculty of previous International Academy of Cardiology meetings who made major contributions to Medicine and Cardiology: MORE»

Dr. Nanette K. Wenger to Deliver 8th HJC Swan Memorial Lecture at Opening of International Academy of Cardiology, Annual Scientific Sessions 2014, 19th World Congress on Heart Disease

Asher KimchiAsher Kimchi, M.D.,Founder and Chairman of the International Academy of Cardiology, today announced that Nanette K. Wenger, M.D., Professor of Medicine in the Division of Cardiology at the Emory University School of Medicine, Atlanta, Georgia, USA, will deliver the eighth H.J.C. Swan Memorial Lecture at the Opening Ceremony of the International Academy of Cardiology, Annual Scientific Sessions 2014, 19th World Congress on Heart Disease, that will be held in Boston, MA, USA, from Friday, July 25 through Monday, July 28, 2014.

Nanette WengerDr. Wenger’s presentation, “Gender Disparity in Coronary Heart Disease: Bias, Biology, or Both?” will provide an overview of current understanding of this challenging clinical problem. Cardiovascular disease remains a major cause of mortality for women both in industrialized economies and in developing nations. A stunning improvement has occurred in cardiovascular disease mortality for U.S. women between 2000 and 2010, attributable both to application of evidence-based therapies of established cardiovascular disease and to preventive interventions; these likely derived from research studies of cardiovascular disease in women.
MORE»


 

 

Invited Speaker Presentations at the
18th World Congress on Heart Disease
(click on the photo to view the video)

18th WORLD CONGRESS ON HEART DISEASE


INFLAMMATION - THE NEW TARGET FOR PREVENTION OF CORONARY ARTERY DISEASE

(click on the photo to view the video)

Roberts
Robert Roberts, M.D.
, University of Ottawa Heart Institute, ON, Canada

New Technology that evolved in 2005 made it possible to genotype the whole human genome sequence utilizing a million DNA markers in the form of single nucleotide polymorphisms (SNPs). This led to the first genome-wide association study (GWAS) in pursuit of the genes for coronary artery disease (CAD). MORE»

PRACTICAL GENETICS OF THORACIC AORTIC ANEURYSM
(click on the photo to view the video)

Elefteriades
John A. Elefteriades, M.D.
, Aortic Institute at Yale-New Haven, CT, USA

The discovery of the genetics of thoracic aortic aneurysm dates back to observations by Hippocrates in 400 BC. The contributions of Marfan, Ehler, and Danlos are well-appreciated. Another germinal advance was the recognition in 1981 by M. David Tilson at Yale that abdominal aortic aneurysm runs in families. MORE»

SEX DIFFERENCES IN CARDIOVASCULAR DISEASE
(click on the photo to view the video)

Regitz_Zagrosek
Vera Regitz-Zagrosek, M.D.
, Center for Cardiovascular Research, Berlin, Germany

Sex differences affect the presentation, treatment results, and outcomes of cardiovascular diseases. Men suffer at younger ages than women from coronary artery disease and hypertension and more commonly develop systolic heart failure or aortic aneurysms. Women are more frequently affected by heart failure with preserved ejection fraction, long QT-syndromes and Tako-tsubo cardiomyopathy. MORE»

CPT1b DEFICIENCY IS BAD FOR THE HYPERTROPHIED HEART
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Yang
Qinglin Yang, M.D.
, University of Alabama at Birmingham, AL, USA

Objective: To investigate the effect of Carnitine palmitoyltransferase 1b (CPT1b) deficiency on pressure overload-induced cardiac hypertrophy. Background: CPT1 is a rate-limiting step of mitochondrial ß-oxidation by controlling the mitochondrial uptake of long-chain acyl-CoAs. MORE»

IS DIABETES REALLY A CORONARY HEART DISEASE RISK EQUIVALENT?
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Wong
Nathan D. Wong, Ph.D.
, University of California, Irvine, CA, USA

Type 2 diabetes (T2DM) is associated with substantial increases in morbidity and mortality from coronary heart disease (CHD) and has been considered a CHD risk equivalent by the US National Cholesterol Education Program. The East-West Study originally showed persons with diabetes but no prior myocardial infarction had a similar risk of future CHD events as those with a prior myocardial infarction and no diabetes. MORE»

INTERACTION OF GENE AND SALT DIETS ON CARDIAC ANGIOTENSIN II, ALDOSTERONE, AND CYTOKINES IN HYPERTROPHIED HEART
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Pandey
Kailash N. Pandey, Ph.D.
, Tulane University School of Medicine, LA, USA

The objective of the present study was to elucidate the interactive roles of guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) gene (Npr1) and salt diets on cardiac angiotensin II (ANG II), aldosterone (ALDO), and pro-inflammatory cytokines in hypertrophied hearts. Npr1 genotypes included gene-disrupted heterozygous (+/-; 1-copy), wild-type (+/+; 2-copy), gene-duplicated heterozygous (++/+; 3-copy), and gene-duplicated homozygous (++/++; 4-copy) mice. Animals were fed with low, normal, and high salt-diets. MORE»

PERSONALIZED MEDICINE IN DILATED CARDIOMYOPATHY
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Mestroni
Luisa Mestroni, M.D.
, University of Colorado, CO, USA

Clinical genetic testing is becoming more mainstream in inherited disorders, such as cardiomyopathies. At the same time, newer DNA sequencing technology can now complete the sequencing of an entire human genome several times over in a matter of days, in an efficient and cost effective manner. However, the extent of remarkable genetic variation is increasingly being appreciated and this undoubtedly adds new challenges to the difficulty of distinguishing true pathogenetic variants from benign variants in diagnostic genetics and in the research setting. MORE»

MITOCHONDRIAL FISSION AND FUSION IN HEART FAILURE
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Knowlton
Anne A. Knowlton, M.D.
, University of California, Davis, CA, USA

Mitochondrial fusion and fission are essential processes for preservation of normal mitochondrial function. OPA1, a mitochondrial fusion protein, is decreased in both human and rat failing hearts. A number of inherited neuropathies are associated with mutation of fission/fusion proteins, including Charcot-Marie-Tooth (CMT) disease. MORE»

NEW INSIGHT INTO TREATMENT OF AORTIC STENOSIS: LIGHT AT THE END OF THE TUNNEL
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Heistad
Donald D. Heistad, M.D.
, University of Iowa, IA, USA

No medical therapy for fibro-calcific aortic valve stenosis (FCAVS) is effective. We have developed experimental models of severe FCAVS in mice, and are using these models to examine interventions that may be useful in slowing the development or progression of FCAVS. MORE»

CAROTID ULTRASOUND EVALUATION OF SUBCLINICAL ATHEROSCLEROSIS IN 2013: PROGRESS AND PITFALLS
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Gardin
Julius M. Gardin, M.D.
, Hackensack University Medical Center, NJ, USA

Carotid artery ultrasound intima-medial thickness (IMT) measurements are reported to add predictive value to traditional risk factors for predicting myocardial infarction and stroke. Recently, we reported that the Lifetime Risk algorithm was superior to both 10-year and 30-year Framingham Risk Score (FRS) algorithms in assigning subjects with carotid or femoral plaques to the high-risk FRS category for women aged 20-to-60 years and for men aged =50 years. MORE»

PREVENTION OF REPERFUSION INJURY IN PATIENTS WITH ST ELEVATION MYOCARDIAL INFARCTION: THE CGMP PATHWAY
(click on the photo to view the video)

Garcia-Dorado
David Garcia-Dorado, M.D., Ph.D.
, Vall d'Hebron University Hospital, Barcelona, Spain

Despite standard-of-the-art reperfusión therapy, most patients with ST elevation myocardial infarction (STEMI) present significant myocardial necrosis, and many of them experience adverse left ventricular remodeling and adverse outcomes. Coadjuvant therapies able to limit necrosis in these patients by reducing reperfusion injury are thus of great potential clinical interest. MORE»

IMPACT OF DENERVATED MYOCARDIUM ON IMPROVING RISK STRATIFICATION FOR SUDDEN CARDIAC DEATH
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Cain
Michael E. Cain, M.D.
, University at Buffalo, NY, USA

The annual incidence of sudden cardiac death in the United States is between 184,000 and 462,000, with estimates that 50% to 70% of the deaths are due to VT or VF. Availability of therapies shown to reduce death in various at-risk groups, including beta-blockers, ACE- inhibitors, statins, aldosterone blockers, and the implantable cardiac defibrillator (ICD), underscore the need to accurately identify patients who will develop VT/VF and exclude those who will not. MORE»

DIHYDROFOLATE REDUCTASE IN CARDIOVASCULAR PATHOPHYSIOLOGY
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Garcia-Dorado
Linda Cai, M.D., Ph.D.
, UCLA David Geffen School of Medicine, CA, USA

It has become clear during the past decade that endothelial nitric oxide synthase (eNOS) can transform into a superoxide-generating/pro-oxidant enzyme, when its essential cofactor tetrahydrobiopterin (H4B) becomes deficient. This phenomenon is now referred to as eNOS uncoupling. MORE»

NOVEL USES OF CARDIAC MRI FOR NON-ISCHEMIC HEART DISEASE
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Biederman
Robert W. W. Biederman, M.D.
, Carnegie Mellon University, PA, USA

While the evaluation of ischemic cardiomyopathy (ICMX) has been well defined via Cardiovascular MRI (CMR), less is understood how the application of similar approaches can be incorporated for the identification non-ischemic cardiomyopathy (NICMX), often defining many obscure diagnoses. The utility for accurate, rapid, inexpensive and robust technique not requiring biopsy confirmation has particular value in the armamentarium of informed clinicians. MORE»

LOW INCOME IS AN INDEPENDENT PREDICTOR OF IN-HOSPITAL MORTALITY AMONG HEART TRANSPLANT RECIPIENTS: A NATIONWIDE INPATIENT SAMPLE STUDY
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Aronow
Wilbert S. Aronow, M.D.
, New York Medical College, NY, U.S.A.

Lower socio-economic condition has been shown to have greater risk of rejection and graft loss among heart transplant recipients who survive the transplant hospitalization. However, the association of income status and in-hospital outcomes among heart transplant recipients have not been studied from a national database. MORE»

CVD IN WOMEN: A FRESH PERSPECTIVE
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Amsterdam
Ezra A. Amsterdam, M.D.
, University of California, Davis, CA, USA

Recognition that cardiovascular disease is the leading cause of mortality in women has stimulated major interest and improvement in the detection, prevention, and treatment of CVD in women. Certain aspects of this subject require further clarification and will be considered in this presentation. MORE»

USEFULNESS OF OPTICAL COHERENCE TOMOGRAPHY IN DAILY CLINICAL PRACTICE
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Akasaka
Takashi Akasaka, M.D., Ph.D.
, Wakayama Medical University, Wakayama, Japan

Recently developed frequency-domain optical coherence tomography (FD-OCT) allow us to obtain 75mm length of high resolution intravascular image (10-20 micrometer) within 3 sec during contrast injection through a guiding catheter. This FD-OCT demonstrates the pathophysiology of the coronary atherosclerosis including vulnerable plaques with thin cap fibroatheroma (TCFA) in vivo before percutaneous intervention (PCI). MORE»

NEW STRATEGIES FOR ACUTE STROKE INTERVENTION
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Sievert
Horst Sievert, M.D., CardioVascular Center Frankfurt, Frankfurt, Germany

Stroke is the third leading cause of death and leading cause of disability in western countries. Though progress has been made in acute stroke intervention with the use of intravenous thrombolytic therapy, a large number of patients remain significantly disabled despite thrombolysis. MORE»

OPTICAL COHERENCE TOMOGRAPHY (OCT): WHAT YOU NEED TO KNOW
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Garcia
Joel A. Garcia, M.D., Denver Health Medical Center (DHMC) and University of Colorado Hospital at Denver, Denver, CO, USA

Objectives: Understanding the technical aspects of Optical Coherence Tomography (OCT) as they apply to daily clinical practice and comparing OCT images and acquisitions to intra-vascular ultrasound (IVUS). MORE»

THE COMPLICATED STEMI: WHAT TO DO WITH MULTIVESSEL DISEASE
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Barsness
Gregory W. Barsness, M.D., Mayo Clinic, Rochester, MN, USA

Primary PCI is the treatment of choice for the majority of patients presenting with myocardial infarction. In many instances, the choice of revascularization strategy is complicated by the presence of multivessel disease, especially in the presence of additional comorbidities, chronic total occlusions and, infrequently, hemodynamic or electrical instability. MORE»

PTEN AND STATINS INDUCED NEW ONSET DIABETES
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Birnbaum
Yochai Birnbaum, M.D., Baylor College of Medicine, Houston, TX, USA

Background: High-dose statin therapy increases the incidence of new-onset diabetes. Studies in animal models have suggested that prolonged statin therapy upregulates Phosphatase and Tensin Homologue on Chromosome 10 (PTEN) expression. PTEN levels are also elevated in the heart, aorta and skeletal muscles of animals with diabetes, as well as the myocardium of diabetic patients. MORE»

THORACOSCOPIC BIATRIAL MAZE PROCEDURE – A NOVEL MINIMAL-INVASIVE REMEDY WITH PROMISING MIDTERM RESULTS
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Khoynezhad
Ali Khoynezhad, M.D., Ph.D., Cedars-Sinai Medical Center, Los Angeles, CA, USA

Minimal Access atrial fibrillation has undergone significant progression in last few years. The lesion set has progressed from simple pulmonary vein (PV) isolation to a more comprehensive lesion set, which can be placed epicardially, and more closely replicates the left atrial lesions of the Cox maze III. Less-invasive access has progressed from bilateral mini thoracotomies initially described by Wolf and coworkers, to a totally thorascopic approach initially described by Puskas and coworkers. MORE»

ENHANCING GLUCOSE OXIDATION AS AN APPROACH TO TREAT 403 HEART FAILURE
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Lopaschuk
Gary Lopaschuk, Ph.D., University of Alberta, Edmonton, AB, Canada

Alterations in cardiac energy metabolism contribute to the impaired heart function observed in heart failure patients. The failing heart is both energy compromised, as well as inefficient at producing energy. MORE»

THE HIGH CORONARY DISEASE RISK OF SOUTH ASIAN AMERICANS
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Klatsky
Arthur L. Klatsky, M.D., Kaiser Permanente Medical Center, Oakland, CA, USA

Objective and Background: Prevalence data and case-control studies suggest high coronary artery disease (CAD) risk in South Asians (SA) but prospective studies remain sparse. We performed a comprehensive prospective analysis in a large population. MORE»

MAJOR NON-CARDIAC SURGERY IN PATIENTS WITH AORTIC STENOSIS - SAME AS 20 YEARS AGO?
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Pislaru
Sorin Pislaru, M.D., Ph.D., Mayo Clinic College of Medicine, Rochester, MN, USA

Severe aortic stenosis has been long recognized as a risk factor for perioperative mortality and morbidity. Current ACC/AHA Guidelines recommend that elective noncardiac surgery be postponed for AS patients until after aortic valve surgery, due to an estimated mortality risk of noncardiac surgery at approximately 10%. MORE»

FAILURE TO OVEREXPRESS UROCORTIN FOLLOWING CARDIOPLEGIC ARREST MAKES THE HEART OF DIABETIC PATIENTS UNDERGOING ON-PUMP CORONARY ARTERY BYPASS GRAFTING MORE SUSCEPTIBLE TO APOPTOSIS AND CARDIAC DYSFUNCTION
(click on the photo to view the video)

Scarabelli
Tiziano M. Scarabelli, M.D., St John Hospital & Medical Center/Wayne State University SOM, Detroit, MI, USA

Background. Molecular mechanisms responsible for the reported worse outcome of diabetic patients (DMP) after on-pump cardiac surgery (OPCS) remain unknown. Opposite effects have been reported for Urocortin (Ucn)/PKCe and PKCd, the former being cardio-protective and the latter pro-apoptotic. MORE»


HIGH SENSITIVITY TROPONINS: A STEP FORWARD OR AN UNREQUESTED COMPLICATION?
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Biasucci
Luigi M. Biasucci, M.D., Catholic University of the Sacred Heart Largo, Rome, Italy

Progressive improvement in the analytical sensitivity of troponin (cTn) assays has led to a more rapid diagnosis of AMI and improved risk stratification in patients with NSTE-ACS, several authors have found that hs-troponin allow a faster and more accurate diagnosis of myocardial infarction (AMI), allowing detection of almost all MI in the first 3 to 6 hours. MORE»

BEYOND HDL CHOLESTEROL: WHAT CAN WE LEARN FROM HDL PARTICLE NUMBER AND SIZE?
(click on the photo to view the video)

Mora
Samia Mora, M.D., Brigham and Women's Hospital, Boston, MA, USA

Given the consistent inverse association of HDL cholesterol (HDL-C) with cardiovascular disease (CVD), there is immense interest in developing therapies that raise HDL-C. But HDL-C, the cholesterol carried by HDL particles, may not fully capture HDL-related cardioprotection. MORE»

THE ASSOCIATION BETWEEN DEPRESSION AND DIABETES
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Barrett-Connor
Elizabeth Barrett-Connor, M.D., UCSD Dept. of Family and Preventive Medicine, La Jolla, CA, USA

Depression increases the risk of mortality, shown in a 12-year follow-up of 10,025 U.S. NHANES adults (Egede LE, Diabetes Care, 2005). Because both diabetes and depression are common, there is considerable overlap by chance alone; a diagnosis of both is most likely to be made in hospitalized patients (Berkson’s bias). MORE»

CALIFORNIA REVASCULARIZATION: PCI OUTCOMES IN THE SUNSHINE STATE
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Bommer
William J. Bommer, M.D., University of California Davis, Medical Center, Davis, CA, USA

Introduction: In California (CA), 141 hospitals perform percutaneous coronary intervention (PCI) with 122 hospitals reporting to the NCDR® CathPCI registry. Objective: To evaluate the PCI volume and composite event outcomes in hospitals with surgery On-site versus hospitals with surgery Off-site in CA. MORE»

HDL AND THE ATHEROSCLEROSIS - MYTH OR REALITY
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Rosenson
Robert S. Rosenson, M.D.
, Mount Sinai Heart Mount Sinai School of Medicine, New York, NY, USA

Low HDL cholesterol (HDL-C) is an established biomarker for the future development of atherosclerosis and atherosclerotic cardiovascular disease (CVD) events in population-based observational studies and clinical trials of cholesterol-lowering therapies and this includes coronary heart disease (CHD) patients with low levels of LDL cholesterol (LDL-C) on statin therapy. MORE»

CARDIAC TISSUE HYPOTHYROIDISM- A MAJOR PLAYER IN DIABETIC CARDIOMYOPATHY
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Gerdes
A. Martin Gerdes, M.D.
, N.Y. Weltman, New York Institute of Technology, Old Westbury, NY, USA

Objectives and Background: Thyroid dysfunction is common in individuals with diabetes mellitus (DM) and may contribute to the associated cardiac dysfunction. However, little is known about the extent and pathophysiological consequences of low thyroid conditions on the heart in DM. MORE»

OXIDATIVE-MECHANICAL SIGNALING ACTIVATES Wnt3a-Lrp5 MEDIATED AORTIC VALVE OSTEOGENESIS IN BICUSPID AORTIC VALVE DISEASE
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Rajamannan
Nalini M. Rajamannan, M.D., Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Introduction: Calcific aortic valve disease (CAVD) is the most common indication for valve surgery in the USA. Cellular mechanisms are under intense investigation. This study hypothesizes that calcific aortic valve disease develops secondary to Wnt3a/Lrp5 activation via oxidative- mechanical stress via a tissue stem cell niche resident in the aortic valve. MORE»

FEMORAL OR RADIAL ACCESS FOR PRIMARY PCI: A DILEMMA OF CHOICE
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Cheema
Asim N. Cheema, M.D., St. Michael's Hospital, Toronto, ON, Canada

Several studies have shown significant reduction in bleeding and vascular complications with transradial percutaneous coronary intervention (PCI) compared to a transfemoral approach. More recently, data from RIVAL and RIFLE-STEACS studies have suggested a mortality benefit in favor of transradial approach for patients undergoing PCI for ST elevation myocardial infarction (STEMI). MORE»

TRENDS IN MANAGEMENT AND OUTCOME OF PATIENTS WITH ACUTE CORONARY SYNDROMES IN THE LAST DECADE: THE ACS ISRAELI SURVEY (ACSIS) EXPERIENCE
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Gottlieb
Shmuel Gottlieb, M.D.
, Jerusalem, Israel

Background: The management of acute coronary syndromes (ACS) patients has undergone major changes during the last decade. These changes reflect the results of numerous controlled clinical trials that established the basis for evidence-based guidelines. MORE»

NON-INVASIVE CARDIOVASCULAR IMAGING FOR EVALUATION OF CORONARY ARTERY BYPASS GRAFT DISEASE
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Elhendy
Abdou Elhendy, M.D., Ph.D
, Department of Cardiology, Marshfield Clinic, Marshfield, WI, USA

Coronary artery bypass graft (CABG) surgery is a widely used method of revascularization in patients with severe coronary artery disease (CAD). Various studies have shown improvement of survival and cardiac symtoms after CABG, particularly in patients with low ejection fraction and multivessel CAD. MORE»

ADVANCES IN PATHOPHYSIOLOGY AND MANAGEMENT OF DIASTOLIC HEART FAILURE
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Chatterjee
Kanu Chatterjee, M.B., FRCP
, The Carver College of Medicine, University of Iowa, Iowa City, IA, USA

Diastolic heart failure is defined as asyndrome of heart failure with preserved ejection fraction (HFPREF). In diastolic heart failure, left ventricular wall thickness and mass is increased and the cavity size is normal. The mass/cavity ratio is increased. MORE»

UPDATE ON THE TREATMENT OF LEFT MAIN DISEASE
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Uretsky
Barry F. Uretsky, M.D.
, University of Arkansas for Medical Sciences, Little Rock, AR, USA

Percutaneous coronary intervention (PCI) with drug eluting stents (DES) has emerged as a treatment alternative with left main (LM) disease. Three randomized clinical trials (RCT) compared DES to coronary artery bypass surgery (CABG). MORE»

DUAL RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM INHIBITION: TOO MUCH OF A GOOD THING?
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Danser
A.H. Jan Danser
, Erasmus MC, Rotterdam, The Netherlands

The beneficial effects of ACE inhibitors (ACEi) and AT1 receptor blockers (ARBs) are due to blockade of tissue Ang II. Such blockade is often incomplete, due to activation of feedback mechanisms within the RAS (‘Ang II escape’). MORE»

SURGICAL TIMING FOR INFECTIVE ENDOCARDITIS
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Kang
Duk-Hyun Kang, M.D., Asan Medical Center, Seoul, South Korea

Despite advances in medical and surgical treatment, infective endocarditis (IE) remains a serious disease that carries considerable mortality and morbidity. The role of surgery has been expanding in IE and early surgery is strongly indicated for IE patients with congestive heart failure or uncontrolled infection, but no randomized trial has been conducted to clarify the indications and optimal timing of surgery because of ethical, logistical and financial constraints. MORE»

INDICATIONS AND SURVIVAL OF 90 YEAR OLDS UNDERGOING CORONARY ANGIOGRAPHY
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Sidhu Mandeep S. Sidhu, M.D., Albany Medical College, Albany, New York, USA

Background: The Elderly are the fastest growing segment of western population. 1 in 5 US Citizen will be elderly by the year 2030. Nonagenarians (>90 year old) are projected to grow to 18 million by the year 2050. MORE»

FLURPIRIDAZ F 18 PET VERSUS TC-99M SPECT FOR MYOCARDIAL PERFUSION IMAGING
(click on the photo to view the video)

Berman Daniel S. Berman, M.D., Cedars-Sinai Medical Center, Los Angeles, CA, USA

Flurpiridaz F-18, a new PET tracer for myocardial perfusion imaging has recently been studied in a Phase II trial. In pre-clinical and phase-I studies, flurpiridaz F-18 has shown essentially linear myocardial uptake throughout the range of flow. MORE»

 

 


Invited Speaker Presentations at the
17th World Congress on Heart Disease
(click on the photo to view the video)

GENETICS OF HEART DISEASE


GENETICS OF CORONARY ARTERY DISEASE

(click on the photo to view the video)

Roberts

Robert Roberts, M.D.
, University of Ottawa Heart Institute, ON, Canada

Susceptibility to coronary artery disease (CAD) is claimed to be 40-60% inherited, but until recently genetic risk factors predisposing to CAD have been elusive. Comprehensive prevention of CAD requires manipulation of genetic risk. The availability of microarrays of single nucleotide polymorphisms enabling genome-wide association studies (GWAS) led to the discovery of 33 genetic risk variants for CAD. MORE»

ISCHEMIC HEART DISEASE

 

PLATELETS AND INFLAMMATION

 

CARDIOPROTECTIVE THERAPIES


 

HEART FAILURE


IS THERE DIFFERENCES IN PATHOPHYSIOLOGY AND VENTRICULAR REMODELING BETWEEN SYSTOLIC AND DIASTOLIC HEART FAILURE
(click on the photo to view the video)

Chatterjee
Kanu Chatterjee, M.D., Medicine University of Iowa, Medicine University of California San Francisco, CA, USA

There are considerable differences in morphology, functional derangements and left ventricular remodeling. Differences in morphology: In systolic heart failure the ventricle dilated and spherical; In diastolic heart failure it is ellipsoidal and non-dilated. MORE»

PERIPARTUM CARDIOMYOPATHY: NEW CONCEPTS IN PATHOPHYSIOLOGY AND MANAGEMENT HEART FAILURE
(click on the photo to view the video)

Elkayam
Uri Elkayam, M.D.,
University of Southern California, Keck School of Medicine, Los Angeles, CA, USA

Peripartum cardiomyopathy(PPCM) is an ididopathic cardiomyopathy presenting with heart failure (HF) due to left ventricular systolic dysfunction towards the end of the pregnancy or in the months following delivery, where no cause of HF is found. A recent animal experimentation has shown that female mice with cardiomyocyte specific knockout of STAT3 developed PPCM. MORE»

ALCOHOL SEPTAL ABLATION VS. SEPTAL MYECTOMY FOR HOCM: WHEN TO DO WHICH
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Fifer
Michael A. Fifer, M.D.,
Massachusetts General Hospital, Boston, MA, USA

Alcohol septal ablation (ASA) was introduced in 1995 as an alternative to surgical septalmyectomy for patients with hypertrophic obstructive cardiomyopathy and symptoms refractory to optimal medical therapy. (No randomized comparative trials of ASA vs. myectomy have been done or planned. MORE»

 

MOLECULAR SURVIVAL AND REGENERATION


 

ARRHYTHMIA AND ELECTROPHYSIOLOGY


NEW INSIGHTS INTO IDENTIFICATION OF PATIENTS AT RISK FOR SUDDEN CARDIAC DEATH

(click on the photo to view the video)

Cain
Michael E. Cain, M.D.,
University at Buffalo, Buffalo, NY, USA

The annual incidence of sudden death (SCD) in the United States is between 184,000 and 462,000, with estimates that 50% to 70% of deaths are due to VT or VF. Availability of therapies that have been shown to reduce SCD in various at-risk groups, including beta-blockers, ACE- inhibitors, statins, aldosterone blockers, and the ICD, underscore the need to accurately identify patients who will develop VT/VF within some specified time period, and exclude those who will not experience SCD. MORE»

IS CARDIAC RESYNCHRONIZATION THERAPY PROARRHYTHMIC?
(click on the photo to view the video)

Curtis
Anne B. Curtis, M.D.,
University of Buffalo, Buffalo, NY, USA

Cardiac resynchronization therapy (CRT) is beneficial in the treatment of patients with systolic heart failure, New York Heart Association (NYHA) Class III-IV symptoms, left ventricular ejection fraction (EF) /=120 ms. CRT leads to improvement in EF and functional capacity, reverse ventricular remodeling, and better survival. MORE»

 

VALVULAR HEART DISEASE


THE IMPACT OF HYPERTENSION AND ITS TREATMENT IN HEART VALVE DISEASE
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Borer
Jeffrey S. Borer, M.D.,
State University of New York Downstate Medical Center, New York, NY, USA

Heart valve diseases cause chronic mechanical (volume and/or pressure) overloads. Beneficial relief of the overloads involves replacement or repair of severely dysfunctional valves, reducing impedance to chamber outflow when valves are stenotic, or reducing volume overload when valves are regurgitant. MORE»

THE ROLE OF LRP5 IN CALCIFIC AORTIC VALVE DISEASE: LDL-DENSITY-PRESSURE THEORY
(click on the photo to view the video)

Rajamannan
Nalini M. Rajamannan, M.D.,
Mayo Clinic, Rochester, MN, USA

Atherosclerosis and osteoporosis are the leading causes of morbidity and mortality in the World. Evidence indicates that hyperlipidemia plays a paradoxical role in both disease processes. However, the mechanism is not understood. The LDL-Density Pressure Theory hypothesizes the role of lipids activate atherosclerosis within the bone and the heart to initiate the development of diseases in both of these tissues. MORE»

 

HYPERTENSION

RENAL DENERVATION-STATE OF THE ART
(click on the photo to view the video)

Bertog
Stefan C. Bertog, M.D.,
Cardiovascular Center Frankfurt, Germany

Systemic hypertension is a major burden to the individual and society. Its association with major adverse cardiac and cerebral events and favorable effects of antihypertensive therapy are undisputed. However, despite multidrug therapy, blood pressures are frequently suboptimally controlled. MORE»

 

 

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